四联疗法治疗根除幽门螺杆菌感染疗效观察

The effects of quadruple regimens for the treatment on helicobacter pylori infection

目的应用四联疗法2周治疗消化性溃疡及慢性胃炎合并H.pylori感染患者疗效。方法患者均经胃镜及C14UBT检查,明确诊断后应用埃索美拉唑镁肠溶片20mg2次/d+胃三联片2次/d口服治疗2周为1个疗程,疗程结束后4周复查C14UBT检查。结果300例患者中消化性溃疡患者为138例、慢性胃炎患者为162例,疗程结束后有281例复查C14UBT,H.pylori感染根除率为91.1%(256/281),消化性溃疡患者与慢性胃炎患者H.pylori感染根除率经统计学处理差异无统计学意义(92.3%比90%)。结论四联疗法在临床上治疗H.pylori感染的疗效确切、费用低、不良反应轻,是理想的根除H.pylori的方法之一。

Objective To study the effect of quadruple regimens for two weeks on the treatment of peptic ulcer and chronic gastritis in combination with H. Pylori infection. Methods Patients with gastroendoscopy and ^14C- urea breath testing （^14C-UBT） confirmed helicobacter pylori infection were administered with esomeprazole 20 mg twice a day. And Weisanlian twice a day （per os） for two weeks. ^14C-UBT examination was carried after cessation of the treatment. Results Among the 300 patients, 138 cases were with peptic ulcer and 162 cases were with chronic gastritis. H. pylori status was assessed by the ^14C-UBT in 281 patients. H. pylori eradication rate was 91.1% （256/281）. There was no statistical difference of H. pylori eradication rate between the peptic ulcer and chronic gastritis （92. 3% vs 90% ）. Conclusion The efficacy of quadruple therapy for H. Pylori infection is sure with low cost and no significant side effects. It is a ideal method for H. pylori eradication.