摘要
目的观察心力衰竭并严重感染患者在应用亚胺培南/西司他丁行抗感染治疗后出现的神经系统不良反应并予分析。方法对5022例心力衰竭并严重感染患者,入院后均予心电监护、外周血氧饱和度监测、呼吸及无创动脉血压监测;按需给予呼吸支持、利尿、强心、减轻心脏负荷、营养支持、内环境稳定维持及并发症处理。同时应用亚胺培南/西司他丁(0.5～1.5g/d)抗感染治疗。结果有4例出现癫痫发作,其发生率为0.8‰;有24例出现失眠、间歇性谵妄、乱语、躁狂、意识不清等症状,发生率为0.5%。结论亚胺培南/西司他丁的神经系统不良反应与年龄、肾功能不全、有癫痫病史、代谢紊乱、低氧血症及所应用剂量明显相关。
Objective To observe and analyse the imipenem/cilastatininduced nerous system side effects in patients with heart failure and severe infection. Methods 5022 patients with heart failure and severe infection were given the electrocardiographic monitoring, oxygen saturation monito in the peripheral blood, respiratory monitoring noninvasive artery blood pressure monitoring after admission and the respiratory support, conventional treatment including strengthening heart, diuresis, lightening heart load, nutritional support homeostasis maintaining and complication management and simultaneous anti-infection treatment with imipenem/cilastatin （0. 5 - 1.5 g/d）. Results 4 cases occurred seizure episodes,the incidence was 0. 8‰,24 cases suffered from insomnia,intermittent delirium gibberish. ,mania,unconsciousness,the incidence was 0. 5%. Conclusion The imipenem/eilastatininduced nerous system side effects is correlated with age, renal insufficiency, epileptic medical history, metabolic disorder, hypoxemia, application doses.
出处
《中国现代药物应用》
2008年第23期30-32,共3页
Chinese Journal of Modern Drug Application
