摘要
Survivin在大多数肿瘤组织中表达,但很少表达于正常组织.他在抑制细胞凋亡,促进肿瘤生长方面发挥重要作用.近几年在胃癌的研究中提示Survivin的表达与胃癌的生物学行为密切相关.鉴于Survivin在肿瘤中表达的特异性,他被认为是胃癌等肿瘤治疗的理想靶点,当前以Survivin为靶点的生物治疗成为新的研究热点.本文就其近几年的研究现状作一综述.
Survivin is a protein highly expressed in a vast number of malignancies while minimally ex- pressed in normal tissues. It plays an important role in inhibiting normal cell death and facilitating cancer cell growth. Studies in recent years indicated that Survivin expression is associated with the biological behviours of gastric carcinoma. Due to this specific expression, Survivin has been considered as an ＂ideal target＂ for cancer therapy. Currently, several pre-clinical and clinical trials are ongoing to investigate the effects of interfering with Survivin function on cancer cells. This paper reviews the progress in Survivin expression in gastric carcinoma and its targeted therapy.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第31期3528-3532,共5页
World Chinese Journal of Digestology
