摘要
环氧合酶-2在溃疡性结肠炎的发生及预后有着重要的作用,首先表现在启动炎症反应过程,许多研究发现COX-2在溃结组织中的表达显著升高,在炎症反应的组织修复期,抑制COX-2则表现为使修复受阻,病情加重.另外COX-2介导的组织修复也需要在一定的严密系统调控下才能正常进行,在各种未知因素的作用下,这个平衡被打破,就有可能出现不典型增生,最终导致癌的发生.
Cycloxygenase-2 （COX-2） plays an important role in the development and prognosis of ulcerative colitis. First, it may initiate inflammatory process. Many studies show that expression of COX-2 is significantly increased in the lesion of ulcerative colitis. During regenerative phase, inhibition of COX-2 may hinder the healing process, and thereafter exacerbate symptoms. COX-2-induced regeneration is monitored under delicate systems. If the balance of this system is disturbed by unknown factors, dysplasia or even carcinoma may develop.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第31期3533-3538,共6页
World Chinese Journal of Digestology
