大肠癌患者血清中sIL-2R、IL-8水平变化及其意义

Pre-and post-operative changes and signif icance of serum sIL-2R and IL-8 in colorectal cancer patients

目的:探讨sIL-2R、IL-8在大肠癌患者术前术后血清中表达及临床意义.方法:双抗体夹心ELISA法检测28例大肠癌患者的sIL-2R、IL-8血清水平;并同时检测大肠息肉患者17例和健康人25例作为对照组.结果:大肠癌患者血清中sIL-2R、IL-8含量明显高于对照组以及大肠息肉组(180.1±83.22 vs 61.3±12.12,52.3±11.21;3.09±0.21 vs 2.49±0.19,2.33±0.18,均P<0.001),手术后显著下降,其中根治组下降显著(80.2±40.31vs114.1±72.3,2.53±0.15 vs 2.81±0.17,均P<0.01),姑息组亦有所下降(242.1±60.3 vs 319.8±67.3,2.77±0.20 vs 3.67±0.19;均P<0.05).大肠癌患者血清sIL-2R、IL-8变化与分化程度呈正相关.结论:动态监测sIL-2R、IL-8的血清表达量有助于临床进行疗效评价,判断大肠癌患者的预后.

AIM： To investigate expressional changes of serum sIL-2R and IL-8 in colorectal cancer patients as well as their clinical significance. METHODS： Serum levels of sIL-2R and IL-8 were measured using the double antibody sandwich ELISA in 28 patients with colorectal cancer before and after operation, 17 cases with intestinal polyp and 25 healthy controls. RESULTS： sIL-2R and IL-8 serum levels were found significantly higher in colorectal cancer patients than that in the intestinal polyp and controls （180.1 ± 83.22 vs 61.3 ± 12.12, 52.3 ± 11.21; 3.09 ± 0.21 vs 2.49 ± 0.19, 2.33 ± 0.18, all P 〈 0.001）. The serum level of sIL-2R and IL-8 declined remarkably after the radical operation （80.2 ± 40.31 vs 114.1 ± 72.3, 2.53 ± 0.15 vs 2.81 ± 0.17, both P 〈 0.01） and decreased after palliative operation （242.1 ± 60.3 vs 319.8 ± 67.3, 2.77 ± 0.20 vs 3.67 ± 0.19, both P 〈 0.05）. Serum changes in sIL-2R and IL-8 were positively correlated with the degree of differentiation in patients with colorectal cancer. CONCLUSION： Dynamic monitoring serum levels of sIL-2R and IL-8 level may be useful for diagnosis and prognosis in colorectal cancer patients.