摘要
趋化因子CCR5,作为G蛋白偶联因子超家族(GPCR)成员的细胞膜蛋白,是HIV-1入侵机体细胞的主要辅助受体之一。以CCR5为靶点的HIV-1受体拮抗剂越来越受关注,主要有趋化因子衍生物、非肽类小分子化合物、单克隆抗体、肽类化合物等4类。这些抗病毒活性强、高亲和力的CCR5拮抗剂,已有一部分进入了临床试验阶段。就近年来CCR5拮抗剂的相关研究进展进行了综述。
Chemokine receptor 5 (CCR5), as a member of the G protein-coupled receptor (GPCR) superfamily, is a membrane protein on cell surface and one of the major of coreceptors for HIV-1 infection. CCR5 has became a molecular target for the novel drugs against HIV-1, and antagonists for CCR5 could be grouped as following, chemokine derivatives, small molecule non-peptide compounds, molecular antibodies and peptides. These compounds with high anti-viral activity and affinity are at different stages, and some have been under clinical studies. Therefore, the development research in the different kind of CCR5 antagonists is reviewed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2008年第11期89-96,共8页
China Biotechnology
基金
国家自然基金(30772722)
广州市科技公关项目(2006Z3-E4101)资助项目