158例肺癌表皮生长因子受体检测及其意义探讨

Study on expression and significance of epidermal growth factor receptor in 158 cases of lung cancer

目的：探讨表皮生长因子受体（ＥＧＦＲ）在肺癌中的表达特征及其临床病理意义。方法：应用ＡＢＣ免疫组织化学法对１５８例肺癌组织进行ＥＧＦＲ检测。结果：非小细胞肺癌的ＥＧＦＲ阳性率为８０．６％，而小细胞肺癌的ＥＧＦＲ均为阴性，并发现非小细胞肺癌ＥＧＦＲ表达与癌的组织学类型、分化程度、生物学行为、肿块大小和临床分期均无相关性。结论：检测肺癌的ＥＧＦＲ有助于鉴别小细胞肺癌和非小细胞肺癌，并认为关于ＥＧＦＲ可能是判断非小细胞肺癌预后的一个与其它因素无关的独立指标。

Purpose To explore the expressional characterics and clinicopathologic significance of epidermal growth factor receptor (EGFR) in lung cancer. Methods The expression of EGFR in 158 lung cancer surgical specimens was studied by the ABC immunohistochemistry technique. Results All 24 small cell lung cancer (SCLC) specimens were negative whereas over 80% of the 134 non small cell lung cancer (NSCLC) stained positively. The positivity rates of EGFR in NSCLC had no direct correlation with histological types, differentiated degrees, biologic behavior, tumorous size and clinical stage of NSCLC. Conclusions The findings suggest that immunohistochemical stainning of EGFR in lung cancer be helpful in differentiating SCLC from NSCLC. The author agrees to the viewpoint that there may be a possible independent prognostic role for EGFR in NSCLC.