琥珀酸单薄荷酯合成工艺的研究

Study on the Synthesis of Monomenthyl Succinate

薄荷醇和琥珀酸酐在4-二甲氨基吡啶的催化作用下,以CHCl3为溶剂,合成凉味剂琥珀酸单薄荷酯。其最佳的反应条件为:薄荷醇与琥珀酸酐的摩尔比为1:1.5,反应时间24h,反应温度为50℃,催化剂与薄荷醇的摩尔比为0.128:1,产物纯度为99.70%,产率为92.50%。

The monomenthyl succinate was synthesized by a direct reaction between succinic anhydride and menthol with DMAP as the catalyst in chloroform with a yield of 92.50N. The optimum conditions for the reaction were as follow：succinic anhydride and menthol in the mole ratio of 1.5： 1; reaction time 24h; reaction temperature 50℃; DMAP and Menthol in the mole ratio of 0. 128：1. Purity of the product is 99. 7%.