即刻种植动物模型的建立及意义

Establishment of Immediate Implant Animal Model in Mongrel Dog's Fresh Extraction Socket

为建立与临床即刻种植相符的动物模型，采用去骨法扩大犬下颌前磨牙新鲜拔牙创和种植直径２ｍｍ自攻螺纹式纯钛种植体，对以往即刻种植动物实验模型加以改进，使种植体植入后其近中留有３ｍｍ×３ｍｍ×５ｍｍ的骨缺损区，设计为异体脱钙冻干骨粒（ＤＦＤＢＡ）植入组和对照组，于术后２周、４周、８周、１２周取材观察骨缺损愈合情况。结果，ＤＦＤＢＡ植入组１２周骨缺损为新骨替代，对照组骨缺损仅修复３／５。该模型制作简便、制模时间短、接近临床。

The purpose of the study was to establish the animal models which had clinical characteristics in bone defect sizes around immediate implants. The mesial region of dogs' fresh extraction sockets were made with 3 mm×3 mm×5 mm size bone defects around implants with a round bur, then observed their osseous changes at 2 weeks, 4 weeks,8 weeks,12 weeks with and without demineralized freezedried bone allograft (DFDBA) filled. The results showed that the bone defects in DFDBA grafted group were substituted by new bone, but the defects in ungrafted group were only substituted to 3/5. Such animal models had the advantages of simple preparations and similar clinical characteristics, so they were beneficial to investigation of the immediate implantion.