摘要
目的：探讨ｎｍ２３－Ｈ１基因在宫颈癌组织中表达及其意义。方法：采用免疫组化法检测宫颈腺癌及鳞癌各３９例癌组织标本中ｎｍ２３－Ｈ１基因表达，采用统计学χ２检验方法，对ｎｍ２３－Ｈ１表达与临床病理因素及预后的关系进行分析。结果：腺癌与鳞癌的表达阳性率分别为４４．６％和３９．２％。在腺癌病例中，Ⅰ期的阳性率为６１．１％，高于Ⅱ期的２８．６％，差异有显著性；术后复发组的阳性率为２１．５％，低于无复发组的５６．０％，差异有显著性；盆腔淋巴结转移组的阳性率为２８．６％，低于无转移组的５２．０％，虽差异无显著意义，然而，淋巴结转移的１４例患者中无１例ｎｍ２３－Ｈ１呈强阳性表达，而淋巴结无转移组２５例中有７例呈强阳性表达，差异有显著性；ｎｍ２３－Ｈ１阳性组的５年生存率（８２．４％），较阴性组（５２．５％）为高，差异有显著性。ｎｍ２３－Ｈ１表达与鳞癌的各临床病理学因素及预后未见明显关系。结论：ｎｍ２３－Ｈ１表达与宫颈腺癌的生物学行为相关，与鳞癌未显示明显关系。
Objective: To investigate the expression of nm23H1 in cervical carcinoma and its signi ficance. Methods: Expression of nm23H1 was examined by immunohistochemical method in 39 cases of adenocarcinoma and 39 cases of squamous cell carcinoma of the uterine cervix. The relationship between expression of nm23H1 and clinicpathologic factors and prognosis was analyzed by chisquare test. Results: Positive staining rate of nm23H1 was 44.6% in adenocarcinoma and 39.2% in squamous cell Carcinoma. The positive staining rate of nm23H1 in stage Ⅰ and Ⅱ adenocarcinoma was 61.1% and 28.6% respectively (P=0.044); in patients with recurrence nm23H1 positive rate was lower than that in patients without recurrence (21.5% vs 56%, P=0.039); in patients with lymph node negative, nm23H1 positive staining was more than that in patients with lymph node positive (52% vs 28.6%), however, this difference was not statistically significant (P=0.162). None of 14 cases of lymph node metastasis was strong positive stainig, whereas 7 of 25 without lymph node metastasis were demonstrated to have strong positive staining (P=0.031). The 5year survival rate in negative staining group was lower than that in the positive stainig group (52.5% vs 82.4%, P=0.042). In squamous cell carcinoma there was no statistically significant relationship between nm23H1 expression and clinicpathologic factors and prognosis. Conclusions: nm23H1 expression was associated with biologic behavior in cervical adenocarcinoma.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1997年第12期718-721,I045,共5页
Chinese Journal of Obstetrics and Gynecology
