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子宫颈癌组织中nm23-H1基因表达与淋巴结转移及预后的关系 被引量:5

Relationship between nm23H1 Expression and Lymph Node Metastasis and Prognosis in Cervical Cancer
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摘要 目的:探讨nm23-H1基因在宫颈癌组织中表达及其意义。方法:采用免疫组化法检测宫颈腺癌及鳞癌各39例癌组织标本中nm23-H1基因表达,采用统计学χ2检验方法,对nm23-H1表达与临床病理因素及预后的关系进行分析。结果:腺癌与鳞癌的表达阳性率分别为44.6%和39.2%。在腺癌病例中,Ⅰ期的阳性率为61.1%,高于Ⅱ期的28.6%,差异有显著性;术后复发组的阳性率为21.5%,低于无复发组的56.0%,差异有显著性;盆腔淋巴结转移组的阳性率为28.6%,低于无转移组的52.0%,虽差异无显著意义,然而,淋巴结转移的14例患者中无1例nm23-H1呈强阳性表达,而淋巴结无转移组25例中有7例呈强阳性表达,差异有显著性;nm23-H1阳性组的5年生存率(82.4%),较阴性组(52.5%)为高,差异有显著性。nm23-H1表达与鳞癌的各临床病理学因素及预后未见明显关系。结论:nm23-H1表达与宫颈腺癌的生物学行为相关,与鳞癌未显示明显关系。 Objective: To investigate the expression of nm23H1 in cervical carcinoma and its signi ficance. Methods: Expression of nm23H1 was examined by immunohistochemical method in 39 cases of adenocarcinoma and 39 cases of squamous cell carcinoma of the uterine cervix. The relationship between expression of nm23H1 and clinicpathologic factors and prognosis was analyzed by chisquare test. Results: Positive staining rate of nm23H1 was 44.6% in adenocarcinoma and 39.2% in squamous cell Carcinoma. The positive staining rate of nm23H1 in stage Ⅰ and Ⅱ adenocarcinoma was 61.1% and 28.6%  respectively (P=0.044); in patients with recurrence nm23H1 positive rate was lower than that in patients without recurrence (21.5% vs 56%, P=0.039); in patients with lymph node negative, nm23H1 positive staining was more than that in patients with lymph node positive (52% vs 28.6%), however, this difference was not statistically significant (P=0.162). None of 14 cases of lymph node metastasis was strong positive stainig, whereas 7 of 25 without lymph node metastasis were demonstrated to have strong positive staining (P=0.031). The 5year survival rate in negative staining group was lower than that in the positive stainig group (52.5% vs 82.4%, P=0.042). In squamous cell carcinoma there was no statistically significant relationship between nm23H1 expression and clinicpathologic factors and prognosis. Conclusions: nm23H1 expression was associated with biologic behavior in cervical adenocarcinoma.
出处 《中华妇产科杂志》 CAS CSCD 北大核心 1997年第12期718-721,I045,共5页 Chinese Journal of Obstetrics and Gynecology
关键词 子宫颈肿瘤 淋巴结转移 NM23-H1基因 Cervix neoplasms Oncogenes Lymphatic metastasis
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参考文献2

  • 1雷文东,中华肿瘤杂志,1994年,16卷,277页
  • 2张惜阴,临床妇科肿瘤学,1993年,99页

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