紫杉醇白蛋白微粒治疗晚期乳腺癌临床观察

Albumin-Bound Particles in Treatment with Advanced Breast Cancer

目的比较紫杉醇白蛋白微粒和以聚氧乙烯蓖麻油为溶剂的紫杉醇治疗晚期乳腺癌的疗效和不良反应。方法共收治晚期乳腺癌21例,随机分为治疗组和对照组。治疗组紫杉醇白蛋白微粒每次剂量260mg/m2,对照组聚氧乙烯蓖麻油为溶剂的紫杉醇每次剂量175mg/m2,均为每3周重复1次。对照组化疗前常规给予地塞米松、西米替丁和苯海拉明预防过敏反应。两组患者各接受了至少4个周期的治疗,每2个周期评价一次疗效。结果治疗组9/9例获得CR+PR,对照组为7/12例。两组均未发生过敏反应,主要不良反应是神经毒性和粒细胞减少。结论紫杉醇白蛋白微粒与以聚氧乙烯蓖麻油为溶剂的紫杉醇相比,疗效相当,治疗组在未进行预防过敏反应处理的情况下,无一例发生过敏反应。

Objective To compare the efficacy and the adverse reactions between albumin-bound particles and polyethylated castor oil-based paclitaxel in treatment of advanced breast cancer. Methods Twenty-one patients were randomly divided into treatment and control groups with 3-week cycles . The dose of treatment group was 260 mg/m^2 , which was 175 mg/m^2 in control group. In control group, dexamethasone, cimetidine and diphenhydramine were given before chemotherapy to prevent allergic reactions. Two groups of patients received at least four cycles of treatment, with assessment of every two cycles. Results In treatment group, 9/9 cases were CR or PR,and in control group was 7/12 cases. No allergic reactions in two groups. The main adverse reactions were neurotoxicity and neutropenia. Conclusion By compare albumin-bound particles and polyethylated castor oil-based paclitaxel, the efficacy was similar, and in treatment group,allergic reactions didn＇t occur without any preventive treatments of allergic reactions.