稀土乙酸8-羟基喹啉三元配合物/羟基磷灰石的纳米有机/无机主客体组装复合抗菌生物材料

Antibacterial composites of nano organic/inorganic: Ternary solid composites of rare earth with acetic acid and 8-hydroxyquinoline/hydroxyapatite

采用湿法原位合成了Tb、Y、Gd3种稀土乙酸8-羟基喹啉三元配合物与羟基磷灰石的纳米有机／无机主客体组装复合材料。通过扫描电子显微镜、X射线粉末衍射、红外光谱对样品进行结构分析测定；采用最低抑菌浓度（MIC）和最低杀菌浓度（MBC）实验来检测其抗菌能力。结果表明，3种复合材料纳米晶平均粒径为50～60nm，皆对金黄葡萄球菌和大肠杆菌具有较高的抗菌作用，并对金黄葡萄球菌的抑制作用强于大肠杆菌。经过对3种复合材料抗菌作用的比较得出抗菌能力的次序为：Tb—HQ／HAP〈Y—HQ／HAP〈Gd—HQ／HAP。

The rare earth （RE： Gd, Y and Tb） complexes of 8 -hydroxyquinoline （8 - HQ） were synthesized. The organic/inorganic hybrid composites, RE- HQ/hydroxyapatite（HAP） were directly prepared via the wet methods. The composites were characterized by means of SEM, XRD and IR. At the same time, the antibacterial activities of all the complexes were tested by using minimum inhibitory concentration （MIC）and minimum bactericidal concentration（MBC）. The results show that the three composites are 50 nm-60 nm in average size and exhibit stronger bacteriostatic activities against Staphylococcus aureus （ S. aureus） and Escherichia coli （E. coli）. They all show higher antibacterial activity against S. aureus than against E. coll. The antibacterial efficacies of the three composites are increased in the order： Tb - HQ/HAP 〈 Y - HQ/HAP 〈Gd - HQ/HAP.