2型糖尿病患者骨密度与颈动脉粥样硬化斑块相关性分析

The relationship between decrease of BMD and carotid atherosclerosis plaque in type 2 diabetes

目的探讨2型糖尿病患者骨量减低相关因素及其与颈动脉粥样硬化斑块之间的相关性。方法341例2型糖尿病患者,行双能X线骨密度测定,同时行双侧颈动脉彩色多普勒检查并进行各项生化指标检测。结果2型糖尿病患者骨量减低组颈动脉粥样硬化斑块发生率高于骨量正常组(P<0.01),女性患者更显著。Logistic回归分析显示骨量减低的影响因素有:性别(P=0.021,OR=1.748)、年龄(P=0.000,OR=1.046)、收缩压(P=0.010,OR=1.018),而有否颈动脉粥样硬化斑块未能进入模型。结论在2型糖尿病患者,颈动脉粥样硬化斑块发生率与骨量减低有关尚不能被证实,两者均受增龄影响,尤其在女性。

Objective To investigate the relative factors of the change of bone mineral density （BMD） and the relationship between decrease of BMD and carotid atherosclerosis plaque in type 2 diabetes （T2DM）. Methods： 341 type 2 diabetes were measured with BMD by dual energy X-ray absorptiometry,biochemistry tests and carotid color uhrasonographic dopplar at the same time. Results： In type 2 diabetes, the occurrence of carotid atherosclerosis plaque in lower bone mass density group is higher than that of normal bone mass density group （P 〈 0.01 ）. Multifactor Logistic regression analysis indicates that sex,age, systolic pressure except carotid atherosclerosis plaque entered the equation. Conclusion： In type 2 diabetes, carotid atherosclerosis plaque probably may have some relationship with decrease of BMD but not the independent risk factor. Age, female and higher systolic pressure are the. independent risk factors of decrease of BMD.