基质GLA蛋白与绝经后骨质疏松症

Matrix gla protein and postmenopausal osteoporosis

基质GLA蛋白(matrix gla protein MGP)是体内软骨内骨形成和血管内钙化的重要调节因子,是矿盐沉积的重要抑制物。近年来发现绝经后妇女在发生骨质疏松症的同时还常伴有血管的钙化,认为两者可能存在着密切的联系。MGP抑制血管钙化同时与骨代谢密切相关。笔者对MGP与绝经后骨质疏松症的关系进行了简要的综述。

Matrix Gla protein （MGP） is the inhibitor of calcification of arteries and cartilage to be characterized in vivo. MGP might inhibit matrix mineralization. Evidences are accumulating that there is a close relationship between bone and vascular calcification and both organs are regulated by common factors in elderly women. Artery calcification inhibiting of MGP is linked to bone resorption. The relationship between MGP and postmenopausal osteoporosis was reviewed briefly in this article.