胃癌患者外周血调节性T细胞的变化及其意义

Expression and clinical significance of T regulatory cells in patients with gastric cancer

目的探讨胃癌患者外周血中CD4＋CD25＋T淋巴细胞、CD8＋CD28-T淋巴细胞比例的变化及其临床意义。方法采用流式细胞技术检测30例胃癌患者外周血中CD4＋CD25＋T淋巴细胞、CD8＋CD28-T淋巴细胞百分比，对照组为30例慢性胃炎患者。结果胃癌患者外周血中CD4＋CD25＋调节性T细胞占T淋巴细胞的百分比为8．7％±1．3％，与胃炎患者相比差异无统计学意义。胃癌患者外周血中CD8＋CD28-调节性T细胞占T淋巴细胞的百分比为30．3％±3．3％，明显高于胃炎患者的20．3％±2．7％。外周血中CD4＋CD25＋T淋巴细胞、CD8＋CD28-T淋巴细胞百分比与胃癌淋巴结转移、病理分型无明显相关性。结论外周血中调节性T细胞在胃癌发展中可能发挥一定作用。

Objective To investigate the proportion changes of the CD4 ＋ CD25 ＋ T cells and CD8 ＋ CD28 - T cells in the peripheral blood of gastric cancer patients. Methods The proportions of CD4 ＋ CD25 ＋ T cells and CD8 ＋ CD28 - T ceils in the peripheral blood of gastric cancer patients were determined by flow cytometry. 30 patients with gastric cancer and 30 patients with chronic gastritis were enrolled in this study. Results Compared with the chronic gastritis controls, the proportion of the CD4 ＋ CD25 ＋ T cells in the peripheral blood of patients with gastric cancer （8.7% ± 1.3% ） was not significantly changed. But the proportion of the CD8 ＋ CD28 - T cell in the peripheral blood of patients with gastric cancer （30. 3% ±3.3% ） was significantly higher than that of control group （20. 3% ±2. 7% ）, P 〈0. 05. There was no significant association between the proportions of T regulatory cells and the lymphomatic metastasis of gastric cancer. No relation was found between the proportions of T regulatory cells and pathological types of gastric cancer. Conclusion CD8 ＋ CD28 - T cells in peripheral blood may be of some value in the progression of gastric cancer.