淋巴上皮样癌的光镜、电镜及免疫组织化学观察

The histological, ultrastructural and immunohistochemical observations of lymphoepitheliomalike carcinoma(LELC)

目的：研究淋巴上皮样癌（ＬＥＬＣ）的本质特征。方法：光镜、电镜和免疫组化Ｃｙｔｏｋｅｒａｔｉｎ、ＥＭＡ、ＣＤ３、ＣＤ４５、ＣＤ２０观察６例ＬＥＬＣ癌细胞及浸润淋巴组织。结果：癌细胞含有张力微丝和桥粒样连接，Ｃｙｔｏｋｅｒａｔｉｎ阳性。浸润的淋巴细胞以Ｔ细胞为主，能直接破坏癌细胞。结论：ＬＥＬＣ是一种具有特殊组织学表现的低分化鳞癌。

Purpose To study the essence of LELC. Methods Six cases of LELC were observed by LM, EM and immunohistochemical technique using cytokeratin, EMA, CD3, CD45, CD20. Results In the carcinoma cells there were tonofibrils and desmosomelike junctions, and cytokeratin positive staining. The infiltrated lymphocytes mainly was T cells and they could kill and destroy the carcinoma cells. Conclusions LELC is a rare poor differential squamous carcinoma possessing particular histological characterics.