犬囊状动脉瘤模型的DSA和病理研究

DSA and pathologic study on experimental saccular aneurysm

目的：探讨动脉瘤的血流动力学及其与动脉瘤发展之间可能的相互关系。方法：用静脉囊镶嵌法将１８条犬制成３种类型（单侧型、分叉型、末梢型）颈总动脉囊状动脉瘤模型，术后２周、４周分别进行ＩＡＤＳＡ检查，然后将犬处死，进行病理研究。结果：ＩＡＤＳＡ不仅可显示动脉瘤的位置、形态、大小、类型、瘤颈和瘤体伸展方向，而且可见瘤体内血液循环状况。不同类型的动脉瘤模型既有相同的血流动力学特征，又有各自的特点，这与动脉瘤与载瘤动脉之间不同形态有关。４周时动脉瘤颈部和顶部有血栓形成。结论：动脉瘤的血流动力学是动脉瘤生长、血栓形成或破裂的重要因素。

Purpose To study the probable relationship between the hemodynamics and the development of aneurysm. Methods A canine model of saccular aneurysm using microsurgical technique was made. Eighteen models (6 lateral, 6 bifurcation, and 6 terminal aneurysms) were constructed and examined with IA DSA in the 2nd and 4th week after the surgical procedure. The dogs were killed for pathologic study following completion of the IA DSA examined. Results The geometrical relationship between an aneurysm and its parent artery was found to be the principal factor that determined the intraaneurysmal flow pattern. Blood flow within experimental aneurysms could all be directly related to the occurrence, growth, thrombosis or rupture of saccular aneurysms. There were thrombosis at the neck and fundus of those aneurysms in the 4th week. Conclusions The hemodynamics of experimental saccular aneurysms determine the growth, thrombosis or rupture of aneurysms.