胃疡宁对实验性胃溃疡的影响

Effect of Weiyangning on experimental gastric ulcer

目的:研究胃疡宁的抗溃疡作用。方法:采用大鼠应激型胃溃疡模型、幽门结扎型胃溃疡模型及醋酸型胃溃疡模型观察抗溃疡作用。结果:胃疡宁(2.24g/kg)可提高醋酸型和应激型胃溃疡愈合率;胃疡宁(2.24g/kg和1.12g/kg)可提高幽门结扎型胃溃疡愈合率。胃疡宁对胃蛋白酶活性和胃泌素均有明显抑制作用。结论:胃疡宁对大鼠实验性胃溃疡具有保护作用。

Objective： To study anti-ulcer effects of Weiyangning. Methods： The effects of anti-ulcer in stress-induced gastric ulcer in rats, pyloric ligation gastric ulcer in rats and acetic acid-gastric ulcer model in rats were observed. Results： Weiyangning （2.24 g/kg） could improve the healing rate of stress-ulcer and acetic acid-gastric ulcer, Weiyangning （2.24 g/kg and 1.12 g/kg） could improve the healing rate of pyloric ligation gastric ulcer. Weiyangning could obviously inhibitactivity of pepsin and gastrin. Conclusion： Weiyangning has protective effect for experimental gastric ulcer in Rats.