二甲双胍临床应用新进展

New clinical application of Metformin

二甲双胍能改善糖脂代谢,改善胰岛素抵抗,减轻体质量,对心血管有良好的保护作用,是众多口服降糖药物中的一线用药,是一线治疗的最佳选择。近年来对二甲双胍降糖作用以外的临床应用研究不断深入,已被应用于多囊卵巢综合征,非酒精性脂肪性肝病等多种疾病的治疗。

Metformin（Met） can improve glycometabolism and lipid metabolism, ameliorate insulin resistance, reduce body weight, and has protective effects on cardiovascular system. Metformin is usually the first-line medication used for treatment of type 2 diabetes mellitus. In recent years, the researches on the clinical application of metformin is not only limited to its role as one of oral hypoglycemic agent, but also the application of the therapy of other diseases , such as polycystic ovarian syndrome, nonalcoholic fatty liver disease and so on. In the near future, more and more studies will be performed.