摘要
目的探讨文拉法辛与阿米替林、氟西汀治疗抑郁症的疗效和不良反应。方法将120例抑郁症患者随机分为文拉法辛组、阿米替林组和氟西汀组,分别给予文拉法辛文拉法辛50～200mg/d、阿米替林50～250mg/d以及氟西汀10～40mg/d治疗,观察6周,采用汉密尔顿抑郁量表和汉密尔顿焦虑量表评分以及副反应量表评定疗效和不良反应。结果文拉法辛组疗效与阿米替林组、氟西汀组比较差异无统计学意义(P>0.05),文拉法辛抗焦虑作用明显优于阿米替林和氟西汀组(P<0.01),文拉法辛组的不良反应和TESS评分和其他两组相比较,均有显著性差异(P<0.01)。结论文拉法辛治疗抑郁症疗效好,起效快,不良反应轻微。
Objective To explore the efficacy and side effects of the venlafaxine, amitriptyline and fluoxetine in the treatment of depression. Methods 120 Cases of depression were randomly divided into three groups, venlafaxine group were given venlafaxine 50-200mg/d and amitriptyline group were given amitriptyline 50-250mg/d as well as fluoxetine group,were given fluoxetine 10-40mg/d, after six weeks,using the Hamilton Depression Scale and Hamilton Anxiety Scale score and vice Scale to assess the efficacy and side effects. Results The difference of the efficacy between the venlafaxine group and amitriptyline group, fluoxetine group was not significant （P 〉 0.05 ）, the anti-anxiety effects of venlafaxine were superior to those of fluoxetine and amitriptyline （P 〈 0.01 ）, the adverse reactions and TESS score were significant difference between the venlafaxine group and the other two groups （P 〈0.01）. Conclusion Venlafaxine is effective, with fast onset of action and minor adverse reactions in treatment of depression.
出处
《中国现代医生》
2008年第34期31-32,34,共3页
China Modern Doctor
