2,4-二氯苯乙酮合成工艺的研究

Study on the synthesis of 2,4-dichloroacetophen

以间-二氯苯为原料，乙酸酐为酰化试剂，合成2，4-二氯苯乙酮。考察影响酰化反应的主要因素，结果表明最适宜的反应条件是：间-二氯苯：乙酸酐的摩尔比为2：1，缓慢滴加乙酸酐时温度保持在50℃左右（低于60℃），然后回流反应温度上升至90～95℃，搅拌并保持约2．5h，最终所得产品收率可达81．8％。

2,4- Dichloroacetophen was＇synthesized with 1,3 -dichlorobenzene as raw material and acetic anhydride as reagent of acylation. The factors that have influence on the action were investigated . The results showed, that the optimal condition were molar ratio of 1,3 -dichlorobenzene to acetic anhydride 2：1 and the temperature around 50℃ （up 60℃ ） of adding acetic anhydride slow, keeping 15 - 20 minutes then the temperature is going up to 90 - 95 ℃ beating up about 2.5 hours ; The yield of 2,4 - dichloroacetophen such conditions was about 81.8%.