湖北省蕲春县褐家鼠对抗凝血灭鼠剂的抗药性研究

Study on the resistant of Rattus norvegicus to anticoagulant rodenticide in Qichun county,Hubei province

目的探讨蕲春县应用抗凝血灭鼠剂以来,褐家鼠对抗凝血灭鼠剂的抗药性变化。方法按全国鼠类抗药性监测协作组统一方法进行抗药性试验。结果在湖北省蕲春县分别于1990年、1995年、2000年、2002年、2005年和2007年进行6次褐家鼠抗药性监测,共208只测试鼠,仅有3次各有1只存活,且后4次监测的试鼠无论雌雄、最低和最高平均致死剂量,都明显低于1995年以前的水平,但平均致死天数较1990年首次监测时有所延长。结论蕲春县在使用抗凝血灭鼠剂灭鼠23年后,褐家鼠对第一代抗凝血灭鼠剂仍高度敏感,对抗凝血药物的耐受能力均低于黄胸鼠和小家鼠,可以继续使用第一代抗凝血灭鼠剂杀灭褐家鼠。

Objective To study the resistant development of Rattus norvegicus to anticoagulant rodenticide after its application in Qichun county. Methods The resistance of R. narvegicus was tested according to the method established by Rodenticide-resistance Monitoring Cooperation Group of China. Results The resistance of R. norvegicus was detected in 1990, 1995, 2000, 2002, 2005 and 2007, respectively. There were 208 rodents tested, and only one rodent survived in each of three times resistance monitoring. Whether the test rodent were male or female, the minimum and maximum average lethal dosages in 2000 - 2008 resistance monitoring was all lower than that in 1995. But the average lethal time postlconed a little compared to that in 1990. Conclusion After the application of anticoagulant rodenticide for 23 years in Qichun, R. norvegicus was still highly susceptible to the first-generation anticoagulant rodenticides, and its tolerance capability was lower than that of R. tanezumi and Mus musculus. Therefore, the anticoagulant rodenticides could be still used to kill R. norvegicus.