香椿总黄酮降血糖作用的实验研究

Experimental Studies on Hypoglycemic Effects of Total Flavonoid from Toona sinensis

目的:研究香椿总黄酮(TSTF)对糖尿病小鼠动物模型的降血糖作用。方法:将四氧嘧啶用NS配成0.02 g/ml,按200 mg/kg注射到小鼠腹腔;连续2 d用葡萄糖灌胃(2 g/kg),早晚各一次,以葡萄糖氧化酶法测空腹血糖,大于11.00 mmol/L为造模成功小鼠。将入选小鼠随机分为模型组、TSTF低、高剂量组(0.06、0.12 g/kg)、降糖灵组(0.10 g/kg),另取20只正常小鼠为对照组(蒸馏水),灌胃1次/d,连续15 d,第16 d用葡萄糖氧化酶法测空腹血糖。结果:TSTF组四氧嘧啶小鼠血糖显著降低。结论:TSTF对四氧嘧啶所致糖尿病模型小鼠有降血糖作用。

Objective： To study hypoglcemic effects of total flavonoid from Toona sinensis （TSTF） on diabetic mice model. Methods ： To confect alloxan 0. 02 g/ml with NS and injected alloxan into abdominal cavity to induce diabetic model, and all rats were fed bid with glucose for 2 consecutive days, then the blood glucose was detected by glucose oxidizes, when hypoglycemic point 〉 11.00 mmol/L the rats were successful model made. 100 model rats were divided into 5 groups as contrast groups （distilled water）, model control control groups, hight doses group（0. 12 g/kg）and low doses group（0. 6 g/kg） of TSTF, positive control groups of phenformin （0. 10 g/kg） ; In addition to set 20 natural rats（ distilled water）, and all groups were fed qd for 15 consecutive days, and then the blood glucose were detected by glucose oxidizes in the sixteenth day. Results：The blood glucose levels of the diabetic rats in TSTF groups significantly decreased. Conclusion ： TSTF can significantly decrease the blood glucose levels of diabetic mice induced by alloxan.