胃食管反流病所致呼吸系统疾病

Gastroesophageal Reflux Disease-induced Respiratory Disease

胃食管反流病可通过反流物激发食管-气道迷走神经反射性地引起气道痉挛和食管内反流物吸入气道内,损害支气管肺组织两种机制导致多种呼吸系统疾病。其发生的病理生理基础与胃食管交界处抗反流屏障、食管体部清除功能和上食管括约肌屏障功能降低以及食管外抗反流功能降低等有关。治疗方面主要是以足量质子泵抑制剂抗反流为主,对于抗反流治疗无效的患者可考虑外科手术治疗。

Gastroesophageal reflux disease（ GERD ）may induce respirator5, system diseases by two ways：airway spasm caused by esophageal-tracheal reflex, and pulmonary-bronchial damage by reflux contents from esophagus inhalation. The pathophysiologleal basis is associated with dysfunction of esophageal-gastric junction antireflux barrier, esophagus body cleaning function, upper esophageal sphincter barrier,and antireflux function outside the esophagus. Treatment focuses on antireflux medicine----full dose of proton pump inhibitor （PPI） principaplly. Surgery methods may be used to those who fail to resonse to medicine.