不同疾病动物模型中的胃肠生物力学和组织结构重构

Biomechanical and Histomorphological Remodeling of GI Tract in Different Animal Models

胃肠生物力学特性对其生理功能至关重要。在不同的病理情况下,胃肠生物力学特性和其组织结构会发生不同程度的重构,因此,用各种不同动物模型研究不同状态和不同疾病情况下GI的生物力学和组织形态重构是非常重要的。在过去十几年间,我们中心采用以种动物模型,如糖尿病模型、肠梗阻模型、饥饿模型、肠切除模型等,对不同状态下胃肠生物力学特性和其组织结构的重构进行了一系列研究。本文对与胃肠道有关的10种不同动物模型的胃肠道的零应力状态,残余应变,应力-应变和管壁组织结构的重构现象进行简单的综述。

Gastrointestinal （GI） biomechanical properties are important for its physiological function. Biomechanical properties and histological structure of GI tract will remodel due to different pathological situations. Therefore, under different physiological situations, such as physiological growth and aging; and different diseases, such as diabetes,obstruction and ulcerative colitis; it is very important to study GI biomechanical and histological remodelling using different animal models. During the past ten years ,we used different animal models, such as, diabetic model, partial intestinal obstruction model, fasting model and intestinal resection model etc, to make series studies related to GI biomechanical and histomorphological remodelling. In this paper,we briefly review the zero-stress state, residual strain, stress-strain and biomeehanical remodelling in the GI tract of 10 different animal models.