雌激素激活血管平滑肌细胞钙激活钾通道的非基因组机制研究进展

The Progress about Non-genomic Mechanisms of Estrogen on Calcium-Activated Potassium Channels of Vascular Smooth Muscle Cells

大电导钙激活钾通道(BKCa)由形成孔道的α亚基及具有调节作用的β亚基组成,因其电导大,对调节平滑肌细胞功能起重要作用,从而成为近年来研究的热点。研究发现雌激素经细胞膜上的雌激素受体介导,通过胞内多种信号转导通路激活内皮型一氧化氮合酶进而产生NO直接或间接激活BKCa通道,产生快速血管效应。随着分子生物学及膜片钳技术的发展,人们在雌激素对BKCa调节机制方面进行了深入的研究,本文就此内容进行综述。

The large-conductance calcium-activated potassium channels （BKCa） channels are consist with α subunit and a regulating role of βsubunit, which has a conductivity, and plays an important role in regulation of smooth muscle cells. It has become a hot research in recent years. Estrogen is mediated by estrogen receptor on cell membrance, activate eNOS through a variety of intracellular signaling pathway, and produce NO, which directly or indirectly activate BKCa channel and make a rapid vascular effect. With the development of molecular biology and patch clamp technology, people have an in-depth study in the regulation mechanism of BKCa by estrogen. This article reviewed these recent research contents.