C反应蛋白与冠状动脉粥样硬化性心脏病

C-reactive Protein and Coronary Heart Disease

冠状动脉粥样硬化性心脏病(CHD)是一种严重危害人类健康的心血管疾病,其病理基础是冠状动脉粥样硬化。炎症在动脉粥样硬化发生、发展过程中起着非常重要的作用,并在一定程度上决定着粥样斑块的稳定性和自然进程。C反应蛋白(CRP)作为炎性反应的一种敏感而非特异性标志物,其介导的补体激活在人类早期动脉粥样硬化中具有重要作用。CRP升高不仅是CHD的危险因子,而且是预测心血管高危事件的重要标志。阿司匹林和他汀类药物可降低血清CRP水平,从而减少心血管事件的发生。

Coronary heart disease （CHD） is a kind of cardiovascular disease doing severe harmful to people＇s health. Its pathological basis is coronary atherosclerosis. Inflammation plays an important role in the occurrence and development of atherosclerosis. Moreover,it determines stability and natural course of atheromatous plaquee at some degree. C-reactive protein（CRP） is a sensitive and a specific marker of inflammation. The complement activation mediated by CRP also plays an important role in early artherosclerosis. Serum CRP level is not only a risk factor of CHD but also a marker forecasting major adverse cardiac events. Aspirin and statins may decrease CRP level and then reduce the occurrence of major adverse cardiac events.