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结核病易感性相关基因-NRAMP1基因的研究进展 被引量：1

Research Progress on the NRAMP1 Gene with Susceptibility to Tuberculosis
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摘要 结核病是由结核杆菌感染引起的慢性传染病,结核病易感性基因(NRAMP1)可影响结核病的发生和发展。Nramp1存在于吞噬小体膜上,通过改变微生物的吞噬体液泡内环境来控制细菌的复制。人类NRAMP1基因多态性与结核病的感染有明显的相关性。本文就NRAMP1基因多态性与结核病的相关性予以综述。 Tuberculosis is a kind of chronic infectious diseases because of infecting tubercle bacillus. The NRAMP1 gene is susceptible to tuberculosis. It can influence the development of tuberculosis. The NRAMP1 exists in the membrane of phagosome and can restrict the bacterial duplication by changing the internal environment of the phagosome pusule. There exist significant correlations of the human NRAMP1 gene polymorphisms and the infection of tuberculosis. This article summarized the development on the association of NRAMP1 gene polymorphisms with susceptibility to tuberculosis.
作者 孟宪杰 张万江
机构地区 石河子大学医学院新疆地方与民族高发病教育部重点实验室
出处 《医学综述》 2008年第23期3588-3589,共2页 Medical Recapitulate
关键词 结核 NRAMP1基因 易感性 Tuberculosis NRAMP1 gene Susceptibility
分类号 R183.3 [医药卫生—流行病学]
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参考文献16

  • 1Rozumek G, Klementowska D, Calka K, et al. Lung tuberculosis in a patient with rheumatoid arthritis--case report [ J ]. J Exp Med, 2007,64 (7/8) :534-537.
  • 2Young DB, Perkins MD, Duncan K, et al. Confronting the scientific obstacles to global control of tuberculosis[ J]. J Clin Invest ,2008, 115(4) :1255-1265.
  • 3Vidal S,Tremblay ML, Govoni G, et al. The hy/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nrampl gene[ J]. J Exp Med, 1995,182 (3) :655-666.
  • 4Vidal SM, Malo D, Vogan K, et al. Natural resistance to infection with intracellular parasites: isolation of a candidate gene for Bcg [ J ]. Cell, 1993,73 (3) :469-485.
  • 5林容,林峰.人类NRAMP1基因与结核分枝杆菌的易感性[J].中国热带医学,2007,7(4):615-616. 被引量：3
  • 6Cellier M, Govoni G, Vital S,et al. Human natural resistance-associated macrophage protein : cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression [ J ]. J Exp Med, 1994,180(5) :1743-1752.
  • 7Fritsche G,Nairz M,Theurl I, et al. Modulation of macrophage iron transport by Nrampl ( Slc11 a1 ) [ J ]. Immunobiology, 2007,212 (9/10) :751-757.
  • 8Huynh C, Andrews NW, et al. Iron acquisition within host cells and the pathogenicity of Leishmania [ J ]. Cell Microbiol,2008,10 ( 2 ) : 293 -300.
  • 9Vidal SM, Malo D, Vogan K, et al. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg [ J ]. Cell, 1993,73 (3) :469-485.
  • 10Liu J, Fujiwara TM, Buu NT,et al. Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene[ J]. Am J Hum Genet, 1995,56 ( 4 ) : 845-853.

二级参考文献40

  • 1肖贞良,钱桂生,夏前明.肺非特异性防御机制的研究进展[J].免疫学杂志,2001,17(z1):129-131. 被引量：4
  • 2[1]Murray CJL, Styblo K, Rouillon A. Tuberculosis in developing countries: burden, intervention and cost[J]. Bull Int Union Tuberc Lung Dis,1990, 65(1):6-24.
  • 3[2]Manolagas SC, Yu XP, Girasole G, et al. Vitamin D and the hematolymphopoietic tissue : a 1994 update[J]. Semin Nephrol, 1994,14(1):129-143.
  • 4[3]Skamene E, Schurr E, Gros P. Infection genomics : Nramp1 as a major determinant of natural resistance to intracellular infections[J]. Annu Rev Med, 1998,49(2):275-287.
  • 5[4]Liu J, Fujiwara TM, Buu NT, et al. Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene[J]. Am J Hum Genet,1995,56(4):845-853.
  • 6[5]Wilkinson RJ, Liewelyn M, Toossi Z, et al. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asian in west London: a case-control study[J]. Lancet,2000,355(9204):618-621.
  • 7[6]Bellamy R, Ruwende C, Corrah T, et al. Variation in the NRAMP1 gene and susceptibility to tuberculosis in west Africans[J]. N Engl J Med, 1998,338(5):640-644.
  • 8[7]Gross C, Eccleshall Tr, Malloy PJ, et al. The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women[J]. J Bone Miner Res, 1996,11(9):1850-1855.
  • 9[8]Bellamy R, Ruwende C, Corrah T, et al. Assessment of the interleukin 1 gene cluster and other candidate gene polymorphisms in host susceptibility to tuberculosis[J]. Tuberc Lung Dis,1998,79(2):83-89.
  • 10Dolin PJ, Raviglione MC, Kochi A. Global tuberculosis incidence and mortality during 1990-2000. Bull WHO, 1994,72:213-220.

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医学综述
2008年 第23期

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