结缔组织生长因子在腹膜纤维化中的作用与调控

Effect and Regulation of Connective Tissue Growth Factor on Peritoneal Fibrosis

腹膜纤维化已逐渐成为维持性腹膜透析患者退出的主要原因,其发生是有多种因素参与的复杂过程。而结缔组织生长因子作为促纤维化刺激的共同下游介质在这一病理生理过程中发挥了重要作用,被认为可能是较理想的抗腹膜纤维化的靶目标。本文就非生理性腹透液致腹膜纤维化的机制、结缔组织生长因子的生物学特性以及结缔组织生长因子在腹膜纤维化发生过程中的具体作用和调控予以综述。

Peritoneal fibrosis has gradually become the main reason for the withdrawal of maintenance peritoneal dialysis patients. Peritoneal fibrosis is a complicated process controlled by various factors. Connective tissue growth factor （ CTGF）, a common downstream mediator of the promoting fibrosis stimulators, has played important effect in this pathophysiological process. Moreover, CTGF is considered to be a better target to prevent peritoneal fibrosis. In this paper, the mechanism of peritoneal fibrosis caused by non-physiologic peritoneal dialysis solutions, the biological characteristics of CTGF, and the effect and regulation of CTGF in the process of peritoneal fibrosis are reviewed.