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CD_(105)在恶性肿瘤中的研究进展 被引量：2

The Research Progress of CD_(105) in Malignant Tumor
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摘要 CD105为内皮细胞表达的糖蛋白,是转化生长因子β(TGF-β)受体超家族的成分之一。CD105是血管内皮细胞增殖的标志之一,同时直接参与血管生成,在肿瘤血管生成过程中发挥重要作用。恶性肿瘤多为富血管性实体性肿瘤,其发生、发展与血管生成密切相关。深入研究CD105在恶性肿瘤中的表达,可能成为恶性肿瘤的诊断、预后、治疗的一条新途径。本文就CD105的结构功能及其在恶性肿瘤的诊治、预后方面的作用进行综述。 CD105 ＇a glycosidoprotein which expressed by endothelial cell, belongs to TGF-β receptor superfamily. As a biomarker of vascular endothelial cells proliferation, CD105 stimulates vasculogenesis and plays key role in tumor angiogenesis. Most malignancies are solid tumors and relate with the development of vasculogenesis. CD105 may be a new pathway for diagnosis, prognosis and treatment of malignant tumor. This paper reviewed the relation between CD105 ＇structure and function in treating and prognosis of malignant tumor.
作者 邱华勤 吴心愿
机构地区 福建医科大学附属协和医院肿瘤科
出处 《医学综述》 2008年第23期3599-3601,共3页 Medical Recapitulate
关键词 恶性肿瘤 血管 生成 CD105 Malignant tumor Vein Generation CD105
分类号 R730.21 [医药卫生—肿瘤]
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参考文献25

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二级参考文献31

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医学综述
2008年 第23期

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