38例氟喹诺酮药物不良反应分析

Analysis on 38 cases of fluoroquinolones adverse drug reaction report

目的通过分析氟喹诺酮类药物不良反应，促进临床合理用药。方法对我院2006～2O07年共报告38例氟喹诺酮类药物不良反应，按照患者病情情况、药品种类、给药途径、不艮反应的表现、转归等进行统计分析。结果在年龄分布上无特异性差异，以静脉炎表现（47．37％）、胃肠道反应（31．57％）、中枢神经系统反应（10．52％）为主。引起不良反应的主要药物种类有环丙沙星、左氧氟沙星、诺氟沙星。静脉给药途径引起的不良反应高于口服给药途径。结论合理使用氟喹诺酮类药物，重视药物不良反应的报告和监测，可减少或避免不良反应的重复发生。

Objective To investigate the occurrence of fluoroquinolones antibiotics adverse drug reactions（ADR） and to promote cases collected in our hospital in 2006 to 2007 rational drug use in the clinic. Method 38 were analyzed retrospectively, fluoroquinolones adverse drug reactions, in accordance with the patient＇s condition, drug type, route of administration, the performance of adverse reactions, such as vesting for statistical analysis. Results The age distribution of non-specific. The mainly manifested adverse drug reaction were phlebitis （47.37%）, gastrointestinal reactions （31.57%）,and lcentral nervous system reaction （10.52%）.Main adverse drug reaction types of ciprofloxacin, levofloxacin, norfloxacin. Intravenous route of administration arising from the adverse effects than oral route of administration. Conclusion The rational use of medication, Importance should be attached to the reporting and monitor of ADR, so as to lessen or avoid the occurrence of ADR in the clinic.