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急性冠状动脉综合征患者SAA,IL-6和IL-1β水平变化及意义 被引量：2

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摘要 目的探讨白细胞介素(IL)-1β、IL-6和血清淀粉样蛋白A(SAA)血清浓度与急性冠状动脉综合征(ACS)发生发展的关系。方法应用ELISA法测定ACS患者[包括急性心肌梗死(AMI)和不稳定型心绞痛(UAP)]治疗前后以及稳定型心绞痛(SAP)患者和对照者血清IL-1β、IL-6和SAA水平。35例心绞痛患者临床随访两年,比较两年内有并发症与无并发症患者初次入院时血清IL-1β、IL-6和SAA水平。结果AMI组和UAP组血清IL-1β、IL-6和SAA水平明显高于SAP组和对照组(P<0.01),其中AMI组最高(P<0.01)。ACS患者经治疗后上述炎症标记物水平均显著降低(P<0.01)。两年内有并发症患者血清SAA和IL-6水平比无并发症患者高(P<0.01)。结论SAA,IL-1β和IL-6不仅在ACS的发生发展过程中起重要作用,而且在临床上可作为诊断ACS,观察治疗效果,评估预后的敏感标志物。
作者 李朝霞 洪国强 陈文思
机构地区 中山大学附属第三医院检验科
出处 《广东医学》 CAS CSCD 北大核心 2008年第12期2054-2056,共3页 Guangdong Medical Journal
关键词 急性冠状动脉综合征 白细胞介素-1Β 白细胞介素一6血清淀粉样蛋白A
分类号 R543.3 [医药卫生—心血管疾病] R742.1 [医药卫生—神经病学与精神病学]
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参考文献9

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广东医学
2008年 第12期

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