摘要
在水溶液中以水杨醛为催化剂,L-精氨酸可以快速消旋为DL-精氨酸.后以DL-精氨酸为底物,利用粪链球菌(Streptococcus faecalis)精氨酸脱亚胺酶对L-精氨酸的专一脱亚胺作用,同时制备D-精氨酸和L-瓜氨酸,分别以92.3%,94.2%的产率获得光学纯的D-精氨酸和L-瓜氨酸.
A practical method for the racemization of L-arginine has been developed. The whole process of racemization by this method can be completed within 6 h in the presence of 0.10 molar equivalent of salicylaldehyde. D-arginine and L-citrulline were produced by means of biotransformation of DL-arginine in the presence of arginine deiminase which was found in the Streptococcus faecalis. The yield of polarimeter analysis of purified D-arginine and L-citrulline was 92.3 % and 94.2 % respectively.
出处
《化学研究》
CAS
2008年第4期52-55,共4页
Chemical Research
基金
国家技术创新基金(02CJ-13-01-16)
徐州医学院院长专项人才基金(07KJZ07)资助项目
