铝暴露对海马NMDA受体的影响

Effect of Aluminum Exposure on NMDA Receptors of Rat Hippocampus

铝是一种慢性神经毒性物质,能影响神经系统的多种功能,特别是对学习和记忆功能有抑制作用。铝可通过改变神经细胞的膜功能和NMDA受体等途径影响细胞内外的钙稳态,造成细胞结构和功能障碍,导致学习记忆能力出现不同程度的下降。NMDA受体是中枢谷氨酸盐兴奋性受体的一种,参与突触可塑性及皮质和海马神经元长时程增强(LTP)效应。NMDA受体通道在学习记忆中开启和学习记忆、神经元可塑性及大脑发育等方面均起重要作用。

Aluminum is one of the chronicity neurovirulence, effects many neurologic functions, especially for learning and memory inhibitory action. Aluminum can change nerve cell pellicula functions and N-methyl-D-Aspartate receptor （NMDA） to influence the calcium balance of cells to cause the cellular structure and functional disturbance, resulting in the different degrees of decline in the learning and memory capacity.NMDA receptor is one of the excitatory receptors of central glutamate, involves in the synaptic plasticity and the long-term enhancement of the cortex and hippocampus ,and plays important roles in opening of learning and memory functions and neuron plasticity and development of cerebrum.