失神经骨骼肌细胞凋亡的研究进展

Progress of Apoptosis in Denervation Induced Muscle Atrophy

骨骼肌失去神经支配后将不可避免地发生萎缩,细胞凋亡被认为是其中的机制之一。细胞凋亡的相关因子参与骨骼肌失神经萎缩,引发细胞凋亡的详细机制和凋亡途径、相关基因的表达、调控因素以及与骨骼肌失神经萎缩的关系目前尚未完全阐明,在某些领域尚存争议。随着对细胞凋亡研究的不断深入,有助于失神经骨骼肌萎缩机制的揭示。

Denervation will unavoidably result in atrophy of the innervated muscles, apoptosis is considered to be one of the atrophy mechanisms. The mechanisms of apoptosis in denervation induced muscle atrophy were mainly discussed in cytology, molecular biology and genomics aspects. By expatiating the correlative factors and pathways of apoptosis in denervation induced muscle atrophy, we introduced the research evolution of apoptosis. The detailed mechanism of apoptosis, genes expression, regulation and the relationship between apoptosis and atrophy are still not well known. However, with the further investigation, more and more scientific evidence would be revealed.