关节软骨组织工程种子细胞的研究进展

PROGRESS IN THE STUDY OF ARTICULAR CARTILAGE TISSUE ENGINEERING SEEDING CELLS

目的综述关节软骨组织工程种子细胞的研究进展。方法广泛查阅近年来有关关节软骨组织工程种子细胞的文献,并进行综述。结果BMSCs分化为软骨细胞将成为关节软骨组织工程种子细胞的主要来源,与支架利用和培养环境改善构成关节软骨组织工程的重要条件。结论充分利用细胞因子和转基因技术,改良三维支架和培养条件,将推动关节软骨组织技术的进展。

Objective To review the latest progress of seeding cells for articular cartilage tissue engineering. Methods The recent original literatures on seeding cells for articular cartilage tissue engineering were extensively reviewed. Results The chondrocytes derived from BMSCs＇ differentiation would be a main source of seeding cells articular cartilage for tissue engineering. Three-dimensional scaffolds and cultivation surroundings played important roles in the field of articular cartilage tissue engineering. Conclusion The utilization of cytokine and transgenic technology as well as improvements of three-dimensional scaffolds and cultivation surroundings will promote the development of articular cartilage tissue engineering.