帕罗西汀合并小剂量奎硫平治疗抑郁症的临床观察

A clinical observation of the effect of paroxetine with small-dose quetiapine in depression

目的:观察帕罗西汀合并小剂量奎硫平(剂量在200 mg/日以下)治疗抑郁症的临床疗效。方法:80例抑郁症患者随机分成帕罗西汀组(单用组)和帕罗西汀合用奎硫平组(合用组)。共观察8周,于治疗前,治疗后1、2、4、6、8周末采用汉密尔顿抑郁量表(HAMD),副反应量表(TESS)评定疗效及不良反应,并随访1年,观察其1年内的复发率。结果:帕罗西汀合用小剂量奎硫平组疗效显著,合用组与单用组的显效率分别为89.2%和70.3%,差异有显著性(P<0.05);治疗后1、2、4周HAMD评分差异有显著性(P<0.05);两组的HAMD因子分在焦虑/躯体化和睡眠障碍方面差异有显著性;TESS评分及1年内复发率无明显差异(P>0.05)。结论:帕罗西汀合用小剂量奎硫平治疗抑郁症起效快,克服了抗抑郁药本身起效慢的特点,可提高疗效,并能迅速改善睡眠障碍和焦虑/躯体化症状,对复发率无明显影响。

Objective：To study the clinical effect of paroxetine with small-dose quetiapine（〈200mg/d） in the treatment of depression. Methods：80 hospitalized patients who met CCMD-3 criteria of depression were randomly divided into search（paroxetine and quetiapine） group and control（paroxetine） group for the treatment of 8 weeks.The efficacy and side effects were evaluated with HAMD and TESS.The relapse of one year was observed by follow up.Results： The treatment of paroxetine with quetiapine was effective and the tolerance was better.There were significant differences in recovery rate,HAMD of first week,second week;forth week and HAMD gene score of symptom of body discomfort,sleep disorder and orexis after treatment between two groups.But there was no difference in TESS and the relapse of one year between two groups.Conclusions： Paroxetine with small-dose quetiapine could improve the efficacy compared with paroxetine in treating depression,and could improve sleep orexis and the feeling of body discomfort..But quetiapine had no distinct effect on relapse.