摘要
目的:比较舍曲林与氯丙咪嗪治疗少年强迫症的临床疗效及不良反应。方法:将61例少年强迫症随机分为氯丙咪嗪组和舍曲林组,疗程均为8周。分别于入组前、服药2、4、8周末应用Yale-Brown强迫量表(Y-BOCS),汉密尔顿抑郁量表(HAMD),汉密尔顿焦虑量表(HAMA)评定疗效,采用副反应量表(TESS)评定不良反应。结果:舍曲林组和氯丙咪嗪组治疗后,Y-BOCS、HAMD、HAMA分值均显著下降,差异无显著性。舍曲林组不良反应发生率明显少于氯丙咪嗪组。结论:舍曲林治疗少年强迫症与氯丙咪嗪疗效相当,不良反应较轻。
Objective：To compare the efficacy and side effects of sertraline and clomipramine in the treatment of child obsessive-compulsive disorders.Methods：A total of 61 patients were randomly assigned to two groups.One group were treated with sertraline and the other with clomipramine for 8 weeks.The efficacy was measured with Y-BOCS 、HAMD and HAMA.The side effects were assessed by TESS.Results： There was no significant difference in the efficacy between sertraline and clomipramine.The side effects of sertraline were lower than those of clomipramine.Conclusions： Sertrline is effective and safe drug in the treatment of child obsessive-complusive disorders.
出处
《中国民康医学》
2008年第23期2757-2757,2797,共2页
Medical Journal of Chinese People’s Health
关键词
氯丙咪嗪
舍曲林
少年强迫症
Sertraline
Clomipramine
Child obsessive-compulsive disorder
