吡柔比星与丝裂霉素膀胱灌注预防浅表性膀胱癌术后复发的疗效对比

A comparative study of the effect of THP and MMC by bladder instillation to treat superficial bladder cancer

目的评价吡柔比星、丝裂霉素膀胱灌注预防浅表性膀胱癌术后复发的临床疗效。方法将145例浅表性膀胱癌按病理分级和临床分期完全随机分为吡柔比星组75例和丝裂霉素组70例，分别用吡柔比星、丝裂霉素作为膀胱灌注治疗药物，观察2组疗效。结果所有患者随访3～36个月，平均19．5个月；吡柔比星组有效率89．3％，复发率10．7％，丝裂霉素组有效率78．6％，复发率21．4％，2组差异有统计学意义（P〈0．05）。结论丝裂霉素耐受性较好，吡柔比星疗效优于丝裂霉素，对预防浅表性膀胱癌术后复发的疗效满意，可作为临床一线药物。

Objective To evaluate the effect of THP and MMC with bladder instillation to treat superficial bladder cancer. Methods A total of 145 patients with superficial bladder cancer were divided into groups randomly. THP by bladder instillation was used in the first group and MMC in the second group. The effects were observed. Results All patients were followed up from 3 to 36 months. The recurrence of bladder cancer in THP group was in 8 patients. The recurrence in MMC group were in 15 patients. Conclusin The MMC has better tolerance compared with THP. The effect of THP is superior to MMC. However, THP has better effect for preventing tumor recurrence so it is the first choice in clinical bladder instillation.