隐匿性乳腺癌与非隐匿性乳腺癌临床特征比较

Comparison of clinical features of occult breast cancer and non-occult breast cancer

目的比较隐匿性乳腺癌与非隐匿性乳腺癌患者的临床特征。方法回顾性分析天津肿瘤医院1981年1月至2000年12月期间收治的96例隐匿性乳腺癌患者的临床病例资料,随机抽取同期入院的女性可手术非隐匿性乳腺癌病例并进行比较。结果隐匿性乳腺癌与非隐匿性乳腺癌患者的ER阳性率分别为42.1%和57.3%,PR阳性率为44.3%和55.9%。隐匿性乳腺癌和非隐匿性乳腺癌不同时期的复发和/或转移率分别为25.6%～66.7%和13.5%～28.2%。隐匿性乳腺癌患者5年、10年总生存率分别为55%和46%;0～Ⅰ期、Ⅱ期及Ⅲ期非隐匿性乳腺癌患者的5年总生存率分别为94%、86%、56%,10年总生存率分别为86%、78%、和47%。结论与非隐匿性乳腺癌相比较,隐匿性乳腺癌ER、PR阳性率低,复发和/或转移率高,5、10年总生存率与Ⅲ期乳腺癌患者相仿。

Objective To compare the clinical features of occult breast cancer and non-occult breast cancer. Methods Clinical data of 96 patients with occult breast cancer treated in Tianjin Cancer Hospital from Jan 1981 to Dec 2000 were retrospectively analyzed and compared with the data of non-occuh breast cancer patients who were sampled randomly in the same period. Results The ER-positive rates of occult breast cancer and non-occuh breast cancer were 42.1% and 57.3% , respectively. The PR-positive rates of occult breast cancer and non-occuh breast cancer were 44.3% and 55.9% , respectively. The recurrence and/or distant metastasis rates of occult breast cancer and non-occuh breast cancer in different periods were 25.6% - 66.7% and 13.5% - 28.2% , respectively. The overall 5- and 10-year survival rates of the 96 patients were 55 % and 46% , respectively. The overall 5-year survival rates of stage 0 - Ⅰ , Ⅱ and Ⅲ of non-occuh breast cancer patients were 94% , 86% and 56% , respectively, and the overall 10-year survival rates were 86% , 78% and 47% , respectively. Conclusion Compared with non-occuh breast cancer patients, the patients of occult breast cancer have low ER/PR-positive rates, high recurrence and/or distant metastasis rates. The overall 5- and 10- year survival rates of occult breast cancer patients are similar to those of stage Ⅲ non-occuh breast cancer.