益气化瘀方治疗糖尿病周围神经血管病52例临床研究

Clinical Observation of Yiqi Huayu Prescription for 52 Cases of Diabetes Peripheral Nerve and Blood Vessel Pathological Change

目的探讨益气化瘀方治疗糖尿病周围神经血管病的临床疗效。方法将100例糖尿病周围神经血管病患者随机分为2组。对照组(48例)采用常规治疗,治疗组(52例)在对照组治疗基础上加用益气化瘀方内服治疗。2组均30日为1个疗程,3个疗程后评定疗效。结果治疗组总有效率92.9%,对照组总有效率61.1%,2组比较差异有统计学意义(P<0.01)。治疗后治疗组糖化血红蛋白、三酰甘油、纤维蛋白原、全血粘度较治疗前明显下降(P<0.01),与对照组比较差异均有统计学意义(P<0.05)。治疗组胆固醇下降程度与对照组相似,差异无统计学意义(P>0.05)。治疗组治疗后腘动脉及足背动脉内径较治疗前增大(P<0.01),峰值流速较治疗前减慢(P<0.01),与对照组比较差异均有统计学意义(P<0.05,P<0.01)。结论益气化瘀方能改善糖尿病周围神经血管病变的临床症状,其机制可能与改善血液粘度有关。

Objective To observe clinical therapeutic effect of Yiqi Huayu Prescription for diabetes peripheral nerve and blood vessel pathological change. Methods One hundred patients with diabetes peripheral nerve and blood vessel pathological change were randomly divided into two groups. The patients in control group （n =48） were treated by routine treatment. The patients in treatment group （n=52） were treated by oral use of Yiqi Huayu Prescription and routine treatment. Their therapeutic effects were compared after three courses of treatment, which was 30 days. Results The total effective rate was 92.9% in the treatment group and 61.1% in the control group. There was significant difference between the two groups （P 〈0.01）. The levels on glycosylated hemoglobin, triglycerides, fibrinogen and blood viscosity of the treatment group were obviously decreased after treatment （P〈0.01）. The descended levels on cholesterol were similar between two groups （P〉0.05）. The internal diameter of the dorsal pedal artery and popliteal artery and the peak value of flow rate of the treatment group were improved （P〈0.01）, and the difference was obvious compared with the control group （P〈0.05, P 〈0.01）. Conclusion Yiqi Huayu Prescription can improve the clinical symptoms of diabetes peripheral nerve and blood vessel pathological change, which may be related to improving blood viscosity.