血清CEA、VEGF检测对恶性胸腔积液诊断及疗效评价的意义

The Significance for Detection of Serum CEA,VEGF in the Diagnosis and Treatment of Malignant Pleural Effusion

目的:探讨血清CEA、VEGF检测对恶性胸腔积液诊断及疗效评价的临床意义。方法:应用ELISA法和放射免疫分析法联合检测恶性胸腔积液患者血清、胸液中CEA、VEGF的含量,观察治疗前后两者的变化,比较血清检测值与胸水检测值的差异,评价血清检测CEA、VEGF的临床价值。结果:恶性组血清及胸液中CEA、VEGF水平均显著高于良性组(P<0.05);两项指标联合检测提高了敏感性血清(88.9%,胸水94.1%)及诊断价值(血清91.8%,胸水/96.7%)。抗癌治疗后两项指标均明显下降(P<0.05)、与胸水检测值相比血清检测值具有相同的敏感性和诊断价值。结论:血清CEA、VEGF检测可用于对恶性胸腔积液诊断及疗效评价。

Objective：To investigate the clinical values of serum carcinoembryonic antigen （CEA）,vascular endothelial growth factor （VEGF） in the diagnosis of malignant pleural effusion and curative effect evaluation. Methods：Serum and pleural fluid specimens were simultaneously collected from patients with malignant pleural effusion.The CEA and VEGF were determined by ELISA method combined radioimmunoassay.To observe their changes prior and post treatment and compare their difference in Serum with in fluid,so as to evaluate the clinical values of serum CEA,VEGF testing.Results：Serum,pleural fluid CEA and VEGF in patients with malignant pleural effusion were significantly higher than those in benign pleural effusion （P〈0.05）.After anti-cancer treatment both of them were dramatcally decreased （p〈0.05）. The sensitivity and diagnostic value for diagnosing malignant pleural effuion enhanced by determination of CEA and VEGF in combination. （The sensitivity was 88.9% in Serum and 94.1% in fluid and the diagnostic value was 91.8% in Serum and 96.7% in fluid）.Compared with fluid determination,Serum determination were isologous sensitivity and diagnosis Value.Conclusion：Determination of CEA and VEGF in serum were valuable for the diagnosis of malignant pleural effusion and evaluation of therapeutic effects.