注射用阿奇霉素对儿童的安全性和不良反应分析

Analysis of azithromycin injection-induced adverse reaction and its safety in children

目的:探讨16岁以下儿童使用注射用阿奇霉素(AZ)的安全性。方法:通过文献检索出有关小儿AZ静脉用药的相关文献及16岁以下儿童使用该药引起ADR的报道,对符合条件的文献按疾病种类、病例数、性别、年龄、剂量、ADR症状及发生时间等进行统计分析。结果:共检索到各类"临床应用"220篇,"个案报道"29篇。文献分布于全国34个省、市。注射用AZ治疗呼吸道细菌、肺炎支原体及恙虫病等感染的有效率均在90以上。不良反应发生率为12.41,主要有消化系统反应、过敏反应和注射部位疼痛,还有引起其它反应的报道。结论:注射用AZ儿童使用较为安全。

Objective：To approach the azithromycin injection-induced adverse reaction and safety in treatment of patients below 16 years. Methods ：Through literature retrieval, azithromycin injection-induced ADRs cases below 16 years reported through internet were collected and analyzed statistically. Results：220 literatures on clinical applications and 29 case reports of azithromycin injections were collected, which were distributed in every province in the country. A total effective rate was obtained more than 90% but for the cases of respiratory infection there was an incidence of 12.41% of mild adverse reaction. The ADRs of azithromycin injection had various manifestations ：mostly allergic reactions, digestive system, injection site ache and others. Conclusions：The result suggests that injectable azithmmycin is effective in treatment of children but with mild adverse reaction.