腺苷蛋氨酸治疗慢性乙型肝炎的系统评价

Systematic Review of Ademetionine for Treating Chronic Hepatitis B

目的:评价腺苷蛋氨酸治疗慢性乙型肝炎的有效性和安全性。方法:电子检索Cochrane图书馆临床对照试验库、MEDLINE、中国生物医学文献数据库、中国期刊全文数据库等数据库及手工检索《中国药学杂志》、《中国新药与临床杂志》等中文核心期刊,查找相关文献,并对纳入研究的结果进行Meta分析。结果:共纳入5个随机对照试验。腺苷蛋氨酸在治疗慢性乙型肝炎时的有效率差异有统计学意义。腺苷蛋氨酸配合基础综合治疗对慢性乙型肝炎退黄效果优于单纯的基础治疗。在治疗慢性乙型肝炎中重度、慢性重型乙型肝炎及肝硬变失代偿时,其退黄效果相似。结论:本系统评价的结果显示腺苷蛋氨酸治疗慢性乙型肝炎有退黄降酶的作用,由于纳入的研究存在选择性偏倚、实施偏倚、测量性偏倚的高度可能性,尚需更多的高质量研究提供可靠的证据对本系统评价的结果予以证实。

Objective：To evaluate the effect and safety of ademetionine for treating chronic hepatitis B. Methods： To search the Cochrane Library, MEDLINE, CBM disk, CNKI, 《 Chinese Pharmaceutical Journal》 《Chinese Journal Of New Drugs and Clinical Remedies》. Data were extracted by two reviewers using a designed extraction form. The quality of included trails was critically assessed. RevMan 4. 2. 2 was used for data analysis. Results：Five randomized controlled trails were included. It showed that ademetionine could abate jaundice better than simple the basis of comprehensive treatment or kuhuang injection in patient with chronic hepatitis B, but less than diammoniumglycyrrihizinate in patients with severe chronic hepatitis B. Ademetionine may abate aminotransferase the same as controlled other medicine in patient with chronic hepatitis B. No fatal side effects were reported. Conclusion： The conclusion should be more specific to the aspects of the trials that need improvement.