胸腔注入尿激酶治疗结核性胸膜炎并积液分隔疗效评价

Clinical Effect Evaluation of Loculated Tuberculous Pleurisy Treated with Intrapleural Urokinase

目的:探讨尿激酶胸腔注入治疗结核性胸膜炎并积液分隔的疗效。方法:确诊的结核性胸膜炎并积液分隔53例,随机分为2组,治疗组27例,对照组26例。穿刺引流尽胸腔积液后,治疗组胸腔注入尿激酶20万U+NS 40 mL,对照组胸腔注入玻璃酸酶1 500 U+NS 40 mL。3～5 d后再次胸腔穿刺引流尽胸腔积液,观察2组用药前后积液范围、积液深度、用药后引流量及毒副反应。结果:治疗组积液范围减少的有效率59.26%,较对照组30.77%有显著性差异(P<0.05)。引流量:治疗组有效率77.78%,较对照组30.77%差异有显著性(P<0.01)。结论:尿激酶胸腔注入治疗结核性胸膜炎并积液分隔是一种简便、有效、较为安全的方法。

Objective：To explore the role of intrapleural injection of urokinase（UK） for patient with loculated tuberculous pleurisy （TP）. Methods： 53 patients with loculated TP were divided into 2 groups randomly,UK（n =27） or hyaluronidase（HA,n =26） plus NS 40ml were injected into the pleural cavity. Results：The therapecutic effect of UK group was better than HA group（ P 〈 0.05）. As comparing the drainage volume of fluid UK group was significantly better than HA group （P〈0.01）. Conclusion： Intrapleural injection of UK is the effective and sofe method for the treatment of loculated TP.