PLGA载多柔比星磁性纳米微球的制备与表征

Preparation and Characterization of Doxorubicin-loaded PLGA Magnetic Nanoparticles

采用复乳法制备了PLGA载多柔比星磁性纳米微球,并对其形貌、粒径、磁性、包封率、载药量等特性进行了表征.实验结果证明,微球形貌良好,粒径分布在20±5 nm范围内,在乳液中分散均匀,具有一定的磁性,微球包封率为41.2%,载药量为0.4%.微球制备方法简便易行,效果良好,各项特性指标符合药物载体要求,在生物活体癌症靶向治疗中具有潜在应用价值.

Doxorubicin-loaded PLGA magnetic nanoparticles were prepared by the double emulsion method. The properties of the nanoparticles such as the morphology, size, magnetism, rate of encapsulation and drug-loading amount were characterized. The results demonstrated that the nanoparticles with magnetism dispersed well in the emulsion. The size of the particles were uniformly distributed in the range of 20±5 nm. The rate of encapsulation and the drug-loading amount were 41.2% and 4%, respectively. The preparation method of the drug-loaded nanoparticles is easy but efficient. The various properties of the particles can meet the need for controlled-released drug carriers. They are good candidates for further development of the targeted anti-cancer treatment of animals and human.