姜黄素的生物活性及构效关系研究进展

Review of the Bioactivity and the Structure-function Relationship of Cureumin

姜黄素是姜黄属植物的主要有效成分，临床应用广泛。但姜黄素水溶性差、体内生物利用率低。本文综述了近年来姜黄素的生物活性及构效关系的研究进展，认为深入研究姜黄素的构效关系并尝试改造姜黄素的结构、研究姜黄素类似物的生物活性，可使姜黄素有望成为防治癌症、心血管疾病、关节炎、阿尔兹海默症、甚至艾滋病的新药。

Curcumin, the active substance of turmeric, has multiple therapeutic activities. However, its water solubility and bio-availability in vivo is very low, which limits the utility of curcumin .This article reviewed recent approaches of the bioactivity and the structure-function relationship of curcumin. The authors suggest that new methods should be tried to modify the structure of curcumin and further studies of therapeutic activities of the homologues are needed.