摘要
姜黄素是姜黄属植物的主要有效成分,临床应用广泛。但姜黄素水溶性差、体内生物利用率低。本文综述了近年来姜黄素的生物活性及构效关系的研究进展,认为深入研究姜黄素的构效关系并尝试改造姜黄素的结构、研究姜黄素类似物的生物活性,可使姜黄素有望成为防治癌症、心血管疾病、关节炎、阿尔兹海默症、甚至艾滋病的新药。
Curcumin, the active substance of turmeric, has multiple therapeutic activities. However, its water solubility and bio-availability in vivo is very low, which limits the utility of curcumin .This article reviewed recent approaches of the bioactivity and the structure-function relationship of curcumin. The authors suggest that new methods should be tried to modify the structure of curcumin and further studies of therapeutic activities of the homologues are needed.
出处
《国际中医中药杂志》
2008年第6期468-470,共3页
International Journal of Traditional Chinese Medicine
基金
国家自然基金资助,编号:30873366