胶原蛋白基因与颅内动脉瘤

Collagen Genes and Intracranial Aneurysm

颅内动脉瘤多因局部脑动脉管壁先天性缺陷和腔内压力增高引起。遗传、吸烟、高血压、脑动脉硬化及血管炎等因素与其发生、发展有关。近年来，随着基因芯片技术的应用，颅内动脉瘤相关致病基因的研究得到了进一步深入，发现了一些与颅内动脉瘤发生密切相关的易感基因，提示颅内动脉瘤可能是一种由多个基因共同作用的多基因疾病。

Intracranial aneurysm often result from congenital defects of regional cerebral artery wall and increased endovascular pressure. Its occurrence and development are associated with several risk factors including genetics, smoking, hypertension, cerebral atherosclerosis and vasculitis. With the application of gene chip technology for the past few years, the research of pathogenic genes associated with intracranial aneurysms was further deepened, and some susceptibility genes closely associated with the occurrence of intracranial aneurysms have been found, and this suggests that intracranial aneurysm may be a polygenic disease caused by the combined action of multiple genes.