血浆孤啡肽水平与抑郁障碍的相关性研究

Relationship between plasma orphanin FQ and major depressive disorder

目的探讨抑郁障碍患者血浆孤啡肽(OFQ)水平的变化。方法应用放射免疫(RIA)法分别测定24例抑郁患者和31例正常人血浆OFQ的浓度。结果1.与对照组相比,抑郁组血浆OFQ水平明显增高(t=2.76,P<0.01),差异有统计学意义。2.抑郁组OFQ含量与HAMD、MADRS总分呈显著正相关(P<0.01)。结论血浆OFQ水平的变化可能参与抑郁障碍的发病机制,并可能提示病情的严重程度。

Objective To explore the relationship between plasma orphanin FQ （QFD）level and major depressive disorder. Methods The plasma concentrations of OFQ in 24 patients with major depressive disorder （MD group） and 31 health adults （control group） were measured by radioimmunoassay（RIA）. Results 1. Compared with the control group, the level of plasma OFQ was significantly higher in MD group（t=2.76, P〈 0.01）. 2. The plasma OFQ level was positively correlated to total scores of HAMD and MADRS（P〈0.01）. Conclusion The change of plasma OFQ level may play an important role in the pathogenesis of major depressive disorder and represent the severity of disease.