高脂血症及冠心病患者载脂蛋白B基因多态性

Apolipoprotein B Gene Polymorphisms in Patients with Hyperlipidemia or Coronary Heart Disease

对１０８例高脂血症患者和１２８例正常血脂者的载脂蛋白Ｂ基因ＸｂａＩ多态性进行分析，结果显示：Ｘ＋（第２６外显子存在多态切点）基因频率为０．０４，远低于西方高加索人种，Ｘ－（无多态切点）基因频率为０．９６。无论正常血脂组成高血脂组，不同基因型（Ｘ＋Ｘ－和Ｘ－Ｘ－）的血浆总胆固醇及甘油三酯水平差别均不显著，高血酯组与正常血酯组相比，Ｘ＋Ｘ－与Ｘ－Ｘ－的发生频率差别也无显著性·冠心病患者６９例与对照７５例的载脂蛋白Ｂ基因ＥｃｏＲＩ多态性分析显示全部于第２９外显子均存在切点。

The Xba I polymorphism of apolipoprotein B gene was studied in 108 hyperlipidemic patients and 128 control subjects. The frequency of the X + allele (presence of cutting site)was 0.04, Which was much lower than that ported in Caucasians. The genotype frequences of X -X - and X +X - did not differ significantly between hyperlipidemic patients and control group. No matter whether it was in the hyperlipidernic or in the control group the plasma cholesterol and triglyceride level showed not much difference between X +X - and X -X - geneotype. The EcoR I restricted site was analysed in 69 coronary heart disease patients and 75 control sub-jects, the results revealed that all of them had a cutting site in exon 29 of apo B gene, no polymorphism was observed.